ASSISTant is a package to assist in performing
Adaptive Subgroup
Selection In
Sequential Trials.
ASSISTant provides a three-stage adaptive group
sequential clinical trial design with provision for selecting a subgroup
where the treatment may be effective. The package provides facilities
for design, exploration and analysis of such trials using either
continuous or discrete outcomes. A complete implementation of the
initial design for the DEFUSE-3 trial is also provided as a
vignette.