PMAPscore: Identify Prognosis-Related Pathways Altered by Somatic Mutation
We innovatively defined a pathway mutation accumulate perturbation score (PMAPscore) to reflect the position and the cumulative effect of the genetic mutations at the pathway level. Based on the PMAPscore of pathways, identified prognosis-related pathways altered by somatic mutation and predict immunotherapy efficacy by constructing a multiple-pathway-based risk model (Tarca, Adi Laurentiu et al (2008) <doi:10.1093/bioinformatics/btn577>).
| Version: |
0.1.1 |
| Depends: |
R (≥ 4.1.0) |
| Imports: |
base, clusterProfiler, glmnet, graphics, grDevices, maftools, org.Hs.eg.db, pROC, stats, survival, survminer, utils |
| Suggests: |
knitr, rmarkdown |
| Published: |
2022-04-12 |
| DOI: |
10.32614/CRAN.package.PMAPscore |
| Author: |
Junwei Han [aut, cre, cph],
Yalan He [aut],
Xiangmei Li [aut] |
| Maintainer: |
Junwei Han <hanjunwei1981 at 163.com> |
| License: |
GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| NeedsCompilation: |
no |
| CRAN checks: |
PMAPscore results |
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