TriadSim: Simulating Triad Genomewide Genotypes

Simulate genotypes for case-parent triads, case-control, and quantitative trait samples with realistic linkage diequilibrium structure and allele frequency distribution. For studies of epistasis one can simulate models that involve specific SNPs at specific sets of loci, which we will refer to as "pathways". TriadSim generates genotype data by resampling triad genotypes from existing data. The details of the method is described in the manuscript under preparation "Simulating Autosomal Genotypes with Realistic Linkage Disequilibrium and a Spiked in Genetic Effect" Shi, M., Umbach, D.M., Wise A.S., Weinberg, C.R.

Version:	0.3.0
Depends:	R (≥ 3.2.2)
Imports:	methods, parallel, snpStats, foreach, doParallel
Suggests:	knitr, rmarkdown
Published:	2021-09-08
DOI:	10.32614/CRAN.package.TriadSim
Author:	Min Shi [aut, cre]
Maintainer:	Min Shi <shi2 at niehs.nih.gov>
License:	GPL-3
NeedsCompilation:	no
Materials:	README NEWS
CRAN checks:	TriadSim results

Documentation:

Reference manual:	TriadSim.pdf
Vignettes:	TriadSim Vignette

Downloads:

Package source:	TriadSim_0.3.0.tar.gz
Windows binaries:	r-devel: TriadSim_0.3.0.zip, r-release: TriadSim_0.3.0.zip, r-oldrel: TriadSim_0.3.0.zip
macOS binaries:	r-release (arm64): TriadSim_0.3.0.tgz, r-oldrel (arm64): TriadSim_0.3.0.tgz, r-release (x86_64): TriadSim_0.3.0.tgz, r-oldrel (x86_64): TriadSim_0.3.0.tgz
Old sources:	TriadSim archive

Linking:

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